This report by the Economic Commission for Latin America and the Caribbean (ECLAC) and the Pan American Health Organization (PAHO) is being published with six years left to meet the Sustainable Development Goals (SDGs) of the 2030 Agenda for Sustainable Development. The combination of the coronavirus disease (COVID-19) pandemic and interrelated and cascading crises has provoked an alarming situation that threatens the attainment of the SDGs globally and in the countries of the region. The multidimensional effects of the pandemic stalled actions linked to achieving various SDGs, causing a regression in 32% of the SDG targets at regional level. This regression is reflected in key health indicators such as maternal mortality, immunization coverage and others related to malnutrition and mental health.