The complex and unprecedented characteristics of the Zika epidemic in Brazil demanded national and local coordination, the intersection of public policies (e.g., health, social assistance, education) and the creation of norms, procedures and protocols to attend the affected families. The epidemic highlighted the difficult living conditions of many marginalised families and emphasised the complex and longstanding challenges involving public health, social development, infrastructure, access to water and sanitation, gender relations and reproductive rights. Besides, since its treatment requires costly treatment and daily care, it has increased vulnerabilities and social inequalities that affect the mothers and children infected by the virus. The objectives of this reasearch were: 1) Analyse the underlying narratives, concepts and agency roles in the build of a social assistance response to the virus-affected population; 2) Understand the social assistance response to the epidemic in the national and local levels as well as the inter-relations between the municipal, state and federal governments; 3) Identify integrated actions that had shaped a social protection response and the intersectionality of the social assistance, health and education sectors; 4) Engagement with partners institutions (Fiocruz, UFPE and UnB) in order to identify complementary topics for research and possible collaboration for publications and future research: and 5) Map governmental actors and other stakeholders involved in the health and social protection response to the Zika epidemic in order to seek future policy engagement activities.