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The Barbados-based MCO comprises 18 UN agencies and covers seven independent nations: Antigua and Barbuda, Barbados, the Commonwealth of Dominica, Grenada, Saint Lucia, Saint Kitts and Nevis, Saint Vincent and the Grenadines and 3 British Overseas territories: Anguilla, the British Virgin Islands and Montserrat.

In keeping with the Global UN Reform, the UN Sub-regional Team (UNST), functions under the leadership of the UN Resident Coordinator. The team supports Members States, through five joint programmes, in pursuit of the Sustainable Development Goals. In alignment with the 2030 Agenda, the UN partners with the Organisation of Eastern Caribbean States (OECS) Commission, the Caribbean Disaster Emergency Management Agency (CDEMA), the private sector, civil society groups and development partners to help governments meet their national priorities and respond to development challenges.