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The Ministry for Foreign Affairs is led by the Minister for Foreign Affairs who is in charge of the government department. The Ministry's highest civil servants are the Secretary of State, who acts as the head of the Office of the Minister, and four Under-Secretaries of State.

The duties of the Ministry are divided between eight departments. The Political Department, Department for External Economic Relations, and Department for Development Policy are responsible for policy coordination.

Regional matters are handled by four departments: Department for Europe; Department for Russia, Eastern Europe and Central Asia; Department for the Americas and Asia; and Department for Africa and the Middle East.