Although much has been written on HIV-sensitive social protection, there is insufficient guidance on how to bring to scale what works in the context of different HIV epidemics and for different populations. This document seeks to fill this gap. It provides guidance to governments, people living with, at risk of or affected by HIV, policy-makers, and other stakeholders on how to intensify the integration of HIV with social protection and other programmes for ending poverty and inequality towards ending AIDS. This document summarizes relevant evidence on social protection, including cash transfers, and on how social protection contributes to the AIDS response. It presents a brief account of the status of progress of Member States in meeting the HIV and social protection target of the 2016 Political Declaration on AIDS. It provides guidance for leveraging and scaling up social protection—in particular, social safety nets, financial incentives and social services—towards achieving the goal of ending AIDS. It does not focus on social security and labour market polices.